DNA Narcolepsy Risk Test
Identifies the HLA-DQB1*06:02 allele linked to a 7 to 25-fold heightened risk of narcolepsy.
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The presence and combination of the HLA-DQB1*06:02 variant can significantly impact the risk of narcolepsy:
- Two copies of HLA-DQB1*06:02: Associated with a 7 to 25 times increased risk of narcolepsy, potentially even up to 250 times increased risk.
- One copy of HLA-DQB1*06:02 along with an alternative HLA-DQB1 allele: Linked to a 3 times increased risk, though this can vary depending on the risk or protective effect of the alternative allele.
- Absence of HLA-DQB1*06:02: Suggests a low risk of developing narcolepsy.
It’s crucial to note that genetics alone cannot be solely responsible for causing narcolepsy. Research indicates that 15 to 25 percent of individuals without the condition still carry the HLA-DQB1*06:02 variant. Furthermore, there are multiple other variants of the HLA-DQB1 gene that provide some protection against narcolepsy, adding complexity to the assessment of an individual’s risk.
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